A clinical trial involving patients with type 1 diabetes (aka: juvenile diabetes) and stem cell therapy has shown that treatment with stem cells can help such patients produce their own insulin.
The stem cells, created from the patients' own blood, proved effective in 13 of 15 subjects in the trial, who no longer need daily insulin injections. However, more studies are needed to verify the findings and learn more about exactly how the therapy works. Experts believe that a widely-available stem cell treatment for type 1 diabetes is at least five years away. The research, furthermore, does not address type 2 diabetes.
The findings were published in the most recent edition of the Journal of the American Medical Association.
Source: London Times
Showing posts with label Diabetes. Show all posts
Showing posts with label Diabetes. Show all posts
Tuesday, August 2, 2011
FDA Diabetes Actos (pioglitazone) Cancer Risk
The U.S. Food and Drug Administration today announced it has begun a safety review of the diabetes drug Actos (pioglitazone), after receiving preliminary results from a long-term observational study designed to evaluate the risk of bladder cancer associated with use of this drug.
The preliminary results are based on five-year data from an ongoing, 10-year observational study by the manufacturer, Takeda Pharmaceuticals North America Inc., San Diego. These early results showed no overall association between Actos exposure and risk of bladder cancer. However, there was an increased risk of bladder cancer in patients with the longest exposure to Actos and in those with the highest cumulative dose of the drug.
Despite this The agency has not concluded that Actos increases the risk of bladder cancer.
Meanwhile a group of Doctors in America have researched a drug free, free of dangerous side effects , way of tackling the Diabetes epidemic now the scourge of the Western World - eat real food! Physicians Committee for Responsible Medicine PCRM are gathering information from ongoing research that shows a Plantarian Diet can have a dramatic effect on type 2 (and in some cases type 1) diabetes.
This is pretty much the same diet used by President Bill Clinton to lose weight and deal with his heart disease.
The Diet does come with a health warning ! The effects are so dramatic that you have to carefully watch your medication and be prepared to reduce the dose otherwise you may have an overdose.
The Food for Life Alliance has recently trained instructors in the diet principles and will soon be conducting a number of free workshops around the UK starting with Stoke , Birmingham and London.
Sunday, July 31, 2011
Why low carbohydrate for diabetes (summary)
If we look at the extremes of substrate source for the provision of bulk calories we have the choice of either fat or carbohydrate.
Under high carbohydrate intake we have high pancreatic insulin output and almost matched hepatic insulin extraction. Some insulin spills over in to the systemic circulation to facilitate bulk glucose utilisation but systemic hyperinsulinaemia and hyperglycaemia should be mild and within physiological limits (whatever they might actually be...). However there is a marked differential between portal vein insulin levels and systemic insulin levels, especially post prandially.
Under extreme ketogenic conditions energy is sourced almost exclusively from lipids. Insulin has minimal involvement with hepatic glucose uptake because almost zero hepatic glucose uptake is going on. Extreme hepatic insulin resistance leads to minimal extraction of what pittance of insulin the pancreas is producing and you end up with the minimal possible difference between portal vein insulin and systemic insulin concentrations.
What happens when someone needs to use insulin to maintain normal blood glucose levels?
If your only route in for exogenous insulin is via peripheral injection you can, with ketosis, put the body in to a state where insulin is relatively unimportant. You do not have to plan for one concentration of insulin to hit adipocytes and muscles while (impossibly) targeting a far higher concentration to hit the liver. Under ketogenic conditions the liver is no longer a sump for insulin usage. In fact there is almost no sump for insulin disposal as it's not being much used for anything. Peripheral and portal insulin requirements are similar and can be met by the peripheral route.
As you move from ketogenic eating to carbohydrate based eating the portal vein to systemic insulin difference has to increase and the problems of controlling hepatic glucose output while still allowing lipolysis to give access to adipose tissue calories becomes progressively more difficult.
It's notable that successful diabetes control, as promoted by people like Dr Bernstein, uses mildly ketogenic macronutrient ratios, ultra extreme ketosis does not appear to be needed. Humans are not mice.
Carbohydrate based diets would appear to lead to that wheelchair in the dialysis room and the incorrect impression that diabetes is an inexorably progressive condition.
Peter
Under high carbohydrate intake we have high pancreatic insulin output and almost matched hepatic insulin extraction. Some insulin spills over in to the systemic circulation to facilitate bulk glucose utilisation but systemic hyperinsulinaemia and hyperglycaemia should be mild and within physiological limits (whatever they might actually be...). However there is a marked differential between portal vein insulin levels and systemic insulin levels, especially post prandially.
Under extreme ketogenic conditions energy is sourced almost exclusively from lipids. Insulin has minimal involvement with hepatic glucose uptake because almost zero hepatic glucose uptake is going on. Extreme hepatic insulin resistance leads to minimal extraction of what pittance of insulin the pancreas is producing and you end up with the minimal possible difference between portal vein insulin and systemic insulin concentrations.
What happens when someone needs to use insulin to maintain normal blood glucose levels?
If your only route in for exogenous insulin is via peripheral injection you can, with ketosis, put the body in to a state where insulin is relatively unimportant. You do not have to plan for one concentration of insulin to hit adipocytes and muscles while (impossibly) targeting a far higher concentration to hit the liver. Under ketogenic conditions the liver is no longer a sump for insulin usage. In fact there is almost no sump for insulin disposal as it's not being much used for anything. Peripheral and portal insulin requirements are similar and can be met by the peripheral route.
As you move from ketogenic eating to carbohydrate based eating the portal vein to systemic insulin difference has to increase and the problems of controlling hepatic glucose output while still allowing lipolysis to give access to adipose tissue calories becomes progressively more difficult.
It's notable that successful diabetes control, as promoted by people like Dr Bernstein, uses mildly ketogenic macronutrient ratios, ultra extreme ketosis does not appear to be needed. Humans are not mice.
Carbohydrate based diets would appear to lead to that wheelchair in the dialysis room and the incorrect impression that diabetes is an inexorably progressive condition.
Peter
Experts vote Vegan Diet Best for Diabetes
 |
| Complete Book of Vegan Cooking |
A vegan diet was voted as joint second in US News Rankings Best Diets section for Diabetes.
Presumably it fell short of first place due to compliance, despite the science, people are hooked on meat and addictive fatty cheese and are yet to discover the delicious alternatives.
Vegan Cookbook - Vegan Diets
Diabetes epidemic affecting 350m
Diabetes epidemic affecting 350m – and western fast food is to blame | Society | The Observer: "More than 350 million people in the world now have diabetes"
Nutritionist and Health Consultant in London Yvonne Bishop-Weston from Foods for Life said
The article in the Guardian reveals
Nutritionist and Health Consultant in London Yvonne Bishop-Weston from Foods for Life said
"I don't mean to be cynical but this sudden media interest in Diabetes does sound like the start of a global PR campaign and I wouldn't be at all surprised if next month we hear there is a new wonder drug for sale"
"Type 2 diabetes can be quite efficiently controlled by diet, and in a number of recent studies Diabetic symptoms have been reversed, just through a high fibre, low fat , low GL plant based Plantarian or healthy vegan diet"
The article in the Guardian reveals
"Diabetes is one of the biggest causes of mortality worldwide, and our study has shown that it is becoming more common almost everywhere. It is set to become the single largest burden on world health care systems," one of the study's main authors, Professor Majid Ezzati, of Imperial College London, told the Observer. "Many nations are going to find it very difficult to cope with the consequences."
This point was backed by Martin Tobias of the ministry of health in New Zealand in an accompanying editorial for the Lancet. As he states, there is "no worldwide surveillance network for diabetes, as there is for communicable diseases such as influenza". Given the inexorable rise in case numbers that is now occurring, there was now "an urgent need" to establish proper monitoring of the disease, he added.
The study – funded by the World Health Organisation and the Gates Foundation – analysed blood from 2.7 million participants aged 25 and over from across the world over a three-year period. Doctors measured levels of glucose in their blood after they had fasted for 12 to 14 hours – blood sugar rises after a meal.
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